• Dinesh Kumar
• Zulphikar Ali
• Ranjit Singh
• Vipin Kumar
• Kusum Lata

In this study a taste masked orodispersible tablets of Tramadol Hydrochloride were prepared and evaluated for comparative in vitro dissolution profile with commercially available market product. The bioequivalence of Test and Reference product of Tramadol Hydrochloride tablets using in vitro multipoint dissolution profile study by UV-Visible spectrophotometry were performed. Dissolution medium were purified water & three different buffer solutions of different pH like pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). The Test and Reference tablets were also evaluated to general quality test of dispersible tablets like weight variation, hardness, friability, disintegration time or dispersion time water absorption ratio, wetting time and assay. Both Test & Reference product were complied with the official specification for uniformity of weight, friability and disintegration time and Assay. The dissolution profiles showed there are no significant change drug release of Test and Reference product of Tramadol Hydrochloride Tablets. The tablets were further analysed for similarity between the dissolution profile of Test and Reference product through determination of difference factor (f1), similarity factor (f2) by calculating the dissolution results of both Test and Reference product at multi time point after 05, 10, 15, 30, 45 minutes. These results similarity factor shows that the both Test and Reference product tablets in this study were bioequivalent.

Dissolution profile, Similarity factor (f2), Tramadol Hydrochloride

"Formulation of Taste Masked Orodispersible Tablets of Tramadol Hydrochloride and Comparative In Vitro Dissolution Profile With Market Product", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.451-458, June-2019, Available :http://www.jetir.org/papers/JETIR1908B58.pdf

"Formulation of Taste Masked Orodispersible Tablets of Tramadol Hydrochloride and Comparative In Vitro Dissolution Profile With Market Product", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp451-458, June-2019, Available at : http://www.jetir.org/papers/JETIR1908B58.pdf