• Padma Bhavani B
• Dr. Sruthi K
• Prof. Sumakanth M
• Samatha D

An orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. If a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". The orphan receptor REVERBA orphan nuclear receptor/DNA complex is studied. The active site is predicted for this protein so further docking studies as well as ligand that are optimally bound to the particular protein can be found through virtual screening and docking studies by using the software such as Pyrx, Autodock. Later on, the toxicity information has been denoted by the use of SwissADME software.

Orphan Receptor, ReV-Erba, indole, Pyrx, Auto dock, binding affinity, virtual screening, molecular docking

"Active Site Structure Prediction, Virtual Screening and Molecular Docking for Ligands of the Reverba Orphan Nuclear Receptor/DNA Complex:1A6Y", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.g276-g298, July-2021, Available :http://www.jetir.org/papers/JETIR2107770.pdf

"Active Site Structure Prediction, Virtual Screening and Molecular Docking for Ligands of the Reverba Orphan Nuclear Receptor/DNA Complex:1A6Y", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppg276-g298, July-2021, Available at : http://www.jetir.org/papers/JETIR2107770.pdf